*Club América 3-2 Cruz Azul
| 13.05.2019 | Cruz Azul | 1-0 | Club América | |
| 10.05.2019 | Club América | 3-1 | Cruz Azul | |
Club Necaxa 1-1 CF Monterrey *
| 13.05.2019 | CF Monterrey | 1-0 | Club Necaxa | |
| 10.05.2019 | Club Necaxa | 1-0 | CF Monterrey | |
Club Tijuana 2-5 Club León *
| 12.05.2019 | Club León | 2-1 | Club Tijuana | |
| 09.05.2019 | Club Tijuana | 1-3 | Club León | |
Pachuca CF 2-2 Tigres UANL *
| 12.05.2019 | Tigres UANL | 1-1 | Pachuca CF | |
| 09.05.2019 | Pachuca CF | 1-1 | Tigres UANL | |