CF Monterrey 1-1 Club Atlas *
| 28.11.2021 | Club Atlas | 1-1 | CF Monterrey | |
| 25.11.2021 | CF Monterrey | 0-0 | Club Atlas | |
Club Puebla 2-3 Club León *
| 29.11.2021 | Club León | 2-0 | Club Puebla | |
| 26.11.2021 | Club Puebla | 2-1 | Club León | |
Santos Laguna 2-2 Tigres UANL *
| 29.11.2021 | Tigres UANL | 1-0 | Santos Laguna | |
| 26.11.2021 | Santos Laguna | 2-1 | Tigres UANL | |
*UNAM Pumas 3-1 Club América
| 28.11.2021 | Club América | 1-3 | UNAM Pumas | |
| 25.11.2021 | UNAM Pumas | 0-0 | Club América | |