Club Puebla 2-11 Club América *
| 16.10.2022 | Club América | 5-1 | Club Puebla | |
| 13.10.2022 | Club Puebla | 1-6 | Club América | |
Cruz Azul 0-3 CF Monterrey *
| 16.10.2022 | CF Monterrey | 3-0 | Cruz Azul | |
| 13.10.2022 | Cruz Azul | 0-0 | CF Monterrey | |
*Deportivo Toluca 6-4 Santos Laguna
| 17.10.2022 | Santos Laguna | 1-2 | Deportivo Toluca | |
| 14.10.2022 | Deportivo Toluca | 4-3 | Santos Laguna | |
Tigres UANL 2-2 Pachuca CF *
| 17.10.2022 | Pachuca CF | 2-1 | Tigres UANL | |
| 14.10.2022 | Tigres UANL | 1-0 | Pachuca CF | |