FC Cahul-2005 0-7 Dacia Chisinau *
| 24.11.2010 | Dacia Chisinau | 7-0 | FC Cahul-2005 | |
| 10.11.2010 | FC Cahul-2005 | 0-0 | Dacia Chisinau | |
FC Iskra-Stal 3-1 CSCA-Rapid
| 24.11.2010 | CSCA-Rapid | 0-2 | FC Iskra-Stal | |
| 10.11.2010 | FC Iskra-Stal | 1-1 | CSCA-Rapid | |
FC Tiraspol 2-5 Sheriff Tiraspol
| 24.11.2010 | Sheriff Tiraspol | 2-0 | FC Tiraspol | |
| 10.11.2010 | FC Tiraspol | 2-3 | Sheriff Tiraspol | |
Olimpia Balti 3-0 Academia UTM
| 24.11.2010 | Academia UTM | 0-1 | Olimpia Balti | |
| 10.11.2010 | Olimpia Balti | 2-0 | Academia UTM | |