*Famalicão U23 3-1 Os Belenenses SAD U23
| 19.04.2021 | Os Belenenses SAD U23 | 0-1 | Famalicão U23 | |
| 13.04.2021 | Famalicão U23 | 2-1 | Os Belenenses SAD U23 | |
*GD Estoril U23 6-2 Portimonense U23
| 19.04.2021 | Portimonense U23 | 2-3 | GD Estoril U23 | |
| 12.04.2021 | GD Estoril U23 | 3-0 | Portimonense U23 | |
Leixões U23 2-3 SL Benfica U23 *
| 20.04.2021 | SL Benfica U23 | 1-1 | Leixões U23 | |
| 14.04.2021 | Leixões U23 | 1-2 | SL Benfica U23 | |
*SC Braga U23 6-4 Marítimo U23
| 20.04.2021 | Marítimo U23 | 2-3 | SC Braga U23 | |
| 13.04.2021 | SC Braga U23 | 3-2 | Marítimo U23 | |