AC Juvenes/Dogana 1-4 SS Pennarossa *
| 27.10.2021 | SS Pennarossa | 2-1 | AC Juvenes/Dogana | |
| 28.09.2021 | AC Juvenes/Dogana | 0-2 | SS Pennarossa | |
*FC Domagnano 3-1 SS San Giovanni
| 26.10.2021 | SS San Giovanni | 0-1 | FC Domagnano | |
| 29.09.2021 | FC Domagnano | 2-1 | SS San Giovanni | |
FC Fiorentino 1-3 SP Tre Fiori *
| 26.10.2021 | SP Tre Fiori | 2-0 | FC Fiorentino | |
| 29.09.2021 | FC Fiorentino | 1-1 | SP Tre Fiori | |
*Folgore Calcio 6-2 AC Libertas
| 27.10.2021 | AC Libertas | 1-5 | Folgore Calcio | |
| 29.09.2021 | Folgore Calcio | 1-1 | AC Libertas | |
*SC Faetano 2-0 SP Cailungo
| 27.10.2021 | SP Cailungo | 0-2 | SC Faetano | |
| 29.09.2021 | SC Faetano | 0-0 | SP Cailungo | |
SS Cosmos 4-7 SP Tre Penne *
| 27.10.2021 | SP Tre Penne | 4-2 | SS Cosmos | |
| 28.09.2021 | SS Cosmos | 2-3 | SP Tre Penne | |