*Arandina CF 1-1 CD Leganés
| 20.01.2011 | CD Leganés | 1-0/p.6-7 | Arandina CF | |
| 11.01.2011 | Arandina CF | 1-0 | CD Leganés | |
Benidorm CF* 1-3 Ontinyent 1931 CF *
| 20.01.2011 | Ontinyent 1931 CF | 1-0 | Benidorm CF* | |
| 11.01.2011 | Benidorm CF* | 1-2 | Ontinyent 1931 CF | |
CD Ronda 2-3 CD Puertollano *
| 19.01.2011 | CD Puertollano | 2-1 AET | CD Ronda | |
| 11.01.2011 | CD Ronda | 1-1 | CD Puertollano | |
*Caravaca CF 3-2 Jerez CF
| 19.01.2011 | Jerez CF | 0-0 | Caravaca CF | |
| 11.01.2011 | Caravaca CF | 3-2 | Jerez CF | |
Montañeros CF 1-4 CF Palencia *
| 19.01.2011 | CF Palencia | 2-1 | Montañeros CF | |
| 11.01.2011 | Montañeros CF | 0-2 | CF Palencia | |
Crevillente Deportivo 1-2 RCD Mallorca B *
| 19.01.2011 | RCD Mallorca B | 1-0 | Crevillente Deportivo | |
| 11.01.2011 | Crevillente Deportivo | 1-1 | RCD Mallorca B | |
CE Sabadell 3-3 Real Zaragoza B *
| 19.01.2011 | Real Zaragoza B | 2-0 | CE Sabadell | |
| 11.01.2011 | CE Sabadell | 3-1 | Real Zaragoza B | |
*SD Lemona 2-0 Racing Santander B*
| 19.01.2011 | Racing Santander B* | 0-0 | SD Lemona | |
| 11.01.2011 | SD Lemona | 2-0 | Racing Santander B* | |