*Betis Deportivo 2-2 CF Villanovense
| 24.01.2018 | CF Villanovense | 2-1 | Betis Deportivo | |
| 10.01.2018 | Betis Deportivo | 1-0 | CF Villanovense | |
Burgos CF 3-3 Pontevedra CF *
| 24.01.2018 | Pontevedra CF | 2-0 | Burgos CF | |
| 10.01.2018 | Burgos CF | 3-1 | Pontevedra CF | |
*FC Vilafranca 6-2 Peña Sport FC
| 24.01.2018 | Peña Sport FC | 2-3 | FC Vilafranca | |
| 10.01.2018 | FC Vilafranca | 3-0 | Peña Sport FC | |
CP Villarrobledo 3-4 Ontinyent 1931 CF *
| 24.01.2018 | Ontinyent 1931 CF | 2-1 | CP Villarrobledo | |
| 10.01.2018 | CP Villarrobledo | 2-2 | Ontinyent 1931 CF | |
*SD Logroñés 5-3 Utebo FC
| 24.01.2018 | Utebo FC | 1-3 | SD Logroñés | |
| 10.01.2018 | SD Logroñés | 2-2 | Utebo FC | |
UCAM Murcia 2-3 Atlético Saguntino *
| 24.01.2018 | Atlético Saguntino | 1-1 | UCAM Murcia | |
| 10.01.2018 | UCAM Murcia | 1-2 | Atlético Saguntino | |
UP Langreo 2-4 UM Escobedo *
| 24.01.2018 | UM Escobedo | 1-2 | UP Langreo | |
| 10.01.2018 | UP Langreo | 0-3 | UM Escobedo | |
UD S.S. Reyes 2-3 UP Plasencia *
| 24.01.2018 | UP Plasencia | 1-0 | UD S.S. Reyes | |
| 11.01.2018 | UD S.S. Reyes | 2-2 | UP Plasencia | |