*AD Alcorcón 3-1 Real Zaragoza
| 21.12.2011 | Real Zaragoza | 0-2 | AD Alcorcón | |
| 13.12.2011 | AD Alcorcón | 1-1 | Real Zaragoza | |
Real Oviedo 0-2 Athletic Bilbao *
| 21.12.2011 | Athletic Bilbao | 1-0 | Real Oviedo | |
| 08.12.2011 | Real Oviedo | 0-1 | Athletic Bilbao | |
*Albacete Balompié 3-1 Atlético Madrid
| 21.12.2011 | Atlético Madrid | 0-1 | Albacete Balompié | |
| 08.12.2011 | Albacete Balompié | 2-1 | Atlético Madrid | |
UD Almería 2-4 CA Osasuna *
| 21.12.2011 | CA Osasuna | 1-1 | UD Almería | |
| 13.12.2011 | UD Almería | 1-3 | CA Osasuna | |
*CD Mirandés 3-1 Villarreal CF
| 21.12.2011 | Villarreal CF | 0-2 | CD Mirandés | |
| 13.12.2011 | CD Mirandés | 1-1 | Villarreal CF | |
Celta de Vigo 2-4 RCD Espanyol *
| 20.12.2011 | RCD Espanyol | 4-2 | Celta de Vigo | |
| 13.12.2011 | Celta de Vigo | 0-0 | RCD Espanyol | |
*Córdoba CF 2-2 Real Betis
| 21.12.2011 | Real Betis | 2-1 | Córdoba CF | |
| 13.12.2011 | Córdoba CF | 1-0 | Real Betis | |
Deportivo La Coruña 4-5 Levante UD *
| 21.12.2011 | Levante UD | 4-1 AET | Deportivo La Coruña | |
| 13.12.2011 | Deportivo La Coruña | 3-1 | Levante UD | |
CE L'Hospitalet 0-10 FC Barcelona *
| 22.12.2011 | FC Barcelona | 9-0 | CE L'Hospitalet | |
| 09.11.2011 | CE L'Hospitalet | 0-1 | FC Barcelona | |
*Racing Santander 6-6 Rayo Vallecano
| 21.12.2011 | Rayo Vallecano | 4-3 | Racing Santander | |
| 13.12.2011 | Racing Santander | 3-2 | Rayo Vallecano | |
SD Ponferradina 1-7 Real Madrid *
| 20.12.2011 | Real Madrid | 5-1 | SD Ponferradina | |
| 13.12.2011 | SD Ponferradina | 0-2 | Real Madrid | |
*Real Sociedad 5-3 Granada CF
| 21.12.2011 | Granada CF | 2-1 | Real Sociedad | |
| 13.12.2011 | Real Sociedad | 4-1 | Granada CF | |
San Roque de Lepe 1-3 Sevilla FC *
| 20.12.2011 | Sevilla FC | 2-1 | San Roque de Lepe | |
| 13.12.2011 | San Roque de Lepe | 0-1 | Sevilla FC | |
*Real Mallorca 2-1 Sporting Gijón
| 20.12.2011 | Sporting Gijón | 0-2 | Real Mallorca | |
| 13.12.2011 | Real Mallorca | 0-1 | Sporting Gijón | |
Cádiz CF 0-4 Valencia CF *
| 22.12.2011 | Valencia CF | 4-0 | Cádiz CF | |
| 13.12.2011 | Cádiz CF | 0-0 | Valencia CF | |