*AD Alcorcón 2-2 RCD Espanyol
| 22.12.2016 | RCD Espanyol | 1-1/p.3-4 | AD Alcorcón | |
| 29.11.2016 | AD Alcorcón | 1-1 | RCD Espanyol | |
Racing Santander 1-5 Athletic Bilbao *
| 22.12.2016 | Athletic Bilbao | 3-0 | Racing Santander | |
| 01.12.2016 | Racing Santander | 1-2 | Athletic Bilbao | |
CD Guijuelo 1-10 Atlético Madrid *
| 20.12.2016 | Atlético Madrid | 4-1 | CD Guijuelo | |
| 30.11.2016 | CD Guijuelo | 0-6 | Atlético Madrid | |
Granada CF 1-2 CA Osasuna *
| 21.12.2016 | CA Osasuna | 2-0 | Granada CF | |
| 30.11.2016 | Granada CF | 1-0 | CA Osasuna | |
UCAM Murcia 0-2 Celta de Vigo *
| 22.12.2016 | Celta de Vigo | 1-0 | UCAM Murcia | |
| 30.11.2016 | UCAM Murcia | 0-1 | Celta de Vigo | |
*Córdoba CF 6-3 Málaga CF
| 20.12.2016 | Málaga CF | 3-4 | Córdoba CF | |
| 30.11.2016 | Córdoba CF | 2-0 | Málaga CF | |
Real Betis 2-3 Deportivo La Coruña *
| 21.12.2016 | Deportivo La Coruña | 3-1 | Real Betis | |
| 29.11.2016 | Real Betis | 1-0 | Deportivo La Coruña | |
Hércules CF 1-8 FC Barcelona *
| 21.12.2016 | FC Barcelona | 7-0 | Hércules CF | |
| 30.11.2016 | Hércules CF | 1-1 | FC Barcelona | |
Gimnàstic Tarragona 0-6 Deportivo Alavés *
| 22.12.2016 | Deportivo Alavés | 3-0 | Gimnàstic Tarragona | |
| 01.12.2016 | Gimnàstic Tarragona | 0-3 | Deportivo Alavés | |
Cultural Leonesa 2-13 Real Madrid *
| 30.11.2016 | Real Madrid | 6-1 | Cultural Leonesa | |
| 26.10.2016 | Cultural Leonesa | 1-7 | Real Madrid | |
Real Valladolid 2-4 Real Sociedad *
| 20.12.2016 | Real Sociedad | 1-1 | Real Valladolid | |
| 01.12.2016 | Real Valladolid | 1-3 | Real Sociedad | |
Sporting Gijón 2-5 SD Eibar *
| 21.12.2016 | SD Eibar | 3-1 | Sporting Gijón | |
| 29.11.2016 | Sporting Gijón | 1-2 | SD Eibar | |
SD Formentera 2-14 Sevilla FC *
| 21.12.2016 | Sevilla FC | 9-1 | SD Formentera | |
| 30.11.2016 | SD Formentera | 1-5 | Sevilla FC | |
SD Huesca 3-4 UD Las Palmas *
| 20.12.2016 | UD Las Palmas | 2-1 | SD Huesca | |
| 01.12.2016 | SD Huesca | 2-2 | UD Las Palmas | |
CD Leganés 2-5 Valencia CF *
| 21.12.2016 | Valencia CF | 2-1 | CD Leganés | |
| 29.11.2016 | CD Leganés | 1-3 | Valencia CF | |
CD Toledo 1-4 Villarreal CF *
| 20.12.2016 | Villarreal CF | 1-1 | CD Toledo | |
| 30.11.2016 | CD Toledo | 0-3 | Villarreal CF | |