| 22.08.2021 | |||
| 19:30 | SD Eibar | 0-1 | SD Ponferradina |
| 17:00 | UD Ibiza | 2-2 | Málaga CF |
| 21.08.2021 | |||
| 22:00 | AD Alcorcón | 0-2 | CF Fuenlabrada |
| 19:30 | CD Tenerife | 0-0 | Sporting Gijón |
| 17:00 | CD Lugo | 0-0 | Real Sociedad B |
| 20.08.2021 | |||
| 22:00 | UD Almería | 2-1 | Real Oviedo |
| 20:00 | Real Valladolid | 2-0 | Real Zaragoza |
| 16.08.2021 | |||
| 22:00 | FC Cartagena | 1-3 | UD Almería |
| 20:00 | Málaga CF | 0-0 | CD Mirandés |
| 15.08.2021 | |||
| 22:00 | CF Fuenlabrada | 1-2 | CD Tenerife |
| 22:00 | UD Las Palmas | 1-1 | Real Valladolid |
| 19:30 | Real Oviedo | 2-2 | CD Lugo |
| 17:00 | Sporting Gijón | 1-0 | Burgos CF |
| 14.08.2021 | |||
| 22:00 | SD Ponferradina | 1-0 | AD Alcorcón |
| 19:30 | Girona FC | 2-0 | SD Amorebieta |
| 17:00 | Real Sociedad B | 1-0 | CD Leganés |
| 13.08.2021 | |||
| 22:00 | Real Zaragoza | 0-0 | UD Ibiza |
| 20:00 | SD Huesca | 2-0 | SD Eibar |
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