Afis Club 0-8 Shorta Damascus *
| 11.01.2011 | Shorta Damascus | 3-0 W.O. | Afis Club | |
| 28.12.2010 | Afis Club | 0-5 | Shorta Damascus | |
*Jaish Damascus 12-1 Ariha
| 12.01.2011 | Ariha | 0-1 | Jaish Damascus | |
| 27.12.2010 | Jaish Damascus | 11-1 | Ariha | |
Wathba Homs 6-0 Harak
| 11.01.2011 | Harak | 0-3 W.O. | Wathba Homs | |
| 28.12.2010 | Wathba Homs | 3-0 W.O. | Harak | |
Hurriya Aleppo 1-11 Foutoua Club *
| 12.01.2011 | Foutoua Club | 4-0 | Hurriya Aleppo | |
| 28.12.2010 | Hurriya Aleppo | 1-7 | Foutoua Club | |
*Ittihad Aleppo 7-3 Afrin SC
| 11.01.2011 | Ittihad Aleppo | 4-2 | Afrin SC | |
| 27.12.2010 | Ittihad Aleppo | 3-1 | Afrin SC | |
Jableh SC 3-3 Nawa'ir Hama *
| 10.01.2011 | Nawa'ir Hama | 1-1 | Jableh SC | |
| 28.12.2010 | Jableh SC | 2-2 | Nawa'ir Hama | |
*Tishreen SC 6-2 Jesser
| 13.01.2011 | Jesser | 1-1 | Tishreen SC | |
| 28.12.2010 | Tishreen SC | 5-1 | Jesser | |
Hutteen Latakia 5-2 Jihad (SYR)
| 11.01.2011 | Jihad (SYR) | 1-1 | Hutteen Latakia | |
| 27.12.2010 | Hutteen Latakia | 4-1 | Jihad (SYR) | |
*Jazeera (SYR) 3-1 Maarrat Al Nu'man
| 10.01.2011 | Maarrat Al Nu'man | 1-0 | Jazeera (SYR) | |
| 28.12.2010 | Jazeera (SYR) | 3-0 | Maarrat Al Nu'man | |
Al Arabi (SYR) 1-5 Majd Damascus *
| 11.01.2011 | Majd Damascus | 2-0 | Al Arabi (SYR) | |
| 28.12.2010 | Al Arabi (SYR) | 1-3 | Majd Damascus | |
Maleeha 2-6 Taliya Hama *
| 11.01.2011 | Taliya Hama | 4-1 | Maleeha | |
| 28.12.2010 | Maleeha | 1-2 | Taliya Hama | |
Daria Club 4-6 Mouhafaza *
| 11.01.2011 | Mouhafaza | 4-0 | Daria Club | |
| 28.12.2010 | Daria Club | 4-2 | Mouhafaza | |
Ommal Quneitra 1-11 Omyyah Idlib *
| 11.01.2011 | Omyyah Idlib | 5-0 | Ommal Quneitra | |
| 28.12.2010 | Ommal Quneitra | 1-6 | Omyyah Idlib | |