Chernomorets Odessa 0-1 Vorskla *
| 27.10.2015 | Vorskla | 0-0 | Chernomorets Odessa | |
| 23.09.2015 | Chernomorets Odessa | 0-1 | Vorskla | |
Olimpik Donetsk 2-5 Dnipro *
| 28.10.2015 | Dnipro | 3-2 | Olimpik Donetsk | |
| 23.09.2015 | Olimpik Donetsk | 0-2 | Dnipro | |
Zirka Kirovohrad 1-3 FK Aleksandriya *
| 28.10.2015 | FK Aleksandriya | 2-0 | Zirka Kirovohrad | |
| 23.09.2015 | Zirka Kirovohrad | 1-1 | FK Aleksandriya | |
Helios Kharkov 1-5 Zorya Luhansk *
| 27.10.2015 | Zorya Luhansk | 3-1 | Helios Kharkov | |
| 23.09.2015 | Helios Kharkov | 0-2 | Zorya Luhansk | |
Obolon-Brovar Kyiv 0-7 Dynamo Kyiv *
| 27.10.2015 | Dynamo Kyiv | 5-0 | Obolon-Brovar Kyiv | |
| 23.09.2015 | Obolon-Brovar Kyiv | 0-2 | Dynamo Kyiv | |
FK Ternopil 0-9 Shakhtar Donetsk *
| 27.10.2015 | Shakhtar Donetsk | 4-0 | FK Ternopil | |
| 23.09.2015 | FK Ternopil | 0-5 | Shakhtar Donetsk | |
Hirnik Kryvyi Rih 2-3 Stal Dniprodzh. *
| 28.10.2015 | Stal Dniprodzh. | 2-1 | Hirnik Kryvyi Rih | |
| 23.09.2015 | Hirnik Kryvyi Rih | 1-1 | Stal Dniprodzh. | |
MFK Mikolaiv 0-7 Volyn Lutsk *
| 28.10.2015 | Volyn Lutsk | 5-0 | MFK Mikolaiv | |
| 23.09.2015 | MFK Mikolaiv | 0-2 | Volyn Lutsk | |