Inter Miami CF 5-6 Atlanta United *
| 10.11.2024 | Inter Miami CF | 2-3 | Atlanta United | |
| 03.11.2024 | Atlanta United | 2-1 | Inter Miami CF | |
| 26.10.2024 | Inter Miami CF | 2-1 | Atlanta United | |
*Los Angeles FC 3-4 Vancouver WC
| 09.11.2024 | Los Angeles FC | 1-0 | Vancouver WC | |
| 04.11.2024 | Vancouver WC | 3-0 | Los Angeles FC | |
| 28.10.2024 | Los Angeles FC | 2-1 | Vancouver WC | |
*Los Angeles Galaxy 9-1 Colorado Rapids
| 02.11.2024 | Colorado Rapids | 1-4 | Los Angeles Galaxy | |
| 27.10.2024 | Los Angeles Galaxy | 5-0 | Colorado Rapids | |
Real Salt Lake 1-1 Minnesota United *
| 03.11.2024 | Minnesota United | 1-1/p.3-1 | Real Salt Lake | |
| 30.10.2024 | Real Salt Lake | 0-0/p.4-5 | Minnesota United | |
FC Cincinnati 2-3 New York City FC *
| 09.11.2024 | FC Cincinnati | 0-0/p.5-6 | New York City FC | |
| 02.11.2024 | New York City FC | 3-1 | FC Cincinnati | |
| 28.10.2024 | FC Cincinnati | 1-0 | New York City FC | |
Columbus Crew 2-3 New York Red Bulls *
| 03.11.2024 | New York Red Bulls | 2-2/p.5-4 | Columbus Crew | |
| 29.10.2024 | Columbus Crew | 0-1 | New York Red Bulls | |
*Orlando City SC 3-1 Charlotte FC
| 10.11.2024 | Orlando City SC | 1-1/p.4-1 | Charlotte FC | |
| 02.11.2024 | Charlotte FC | 0-0/p.3-1 | Orlando City SC | |
| 28.10.2024 | Orlando City SC | 2-0 | Charlotte FC | |
*Seattle Sounders 1-1 Houston Dynamo
| 04.11.2024 | Houston Dynamo | 1-1/p.6-7 | Seattle Sounders | |
| 29.10.2024 | Seattle Sounders | 0-0/p.5-4 | Houston Dynamo | |