CA Cerro 2-2 Defensor Sporting *
| 04.12.2021 | Defensor Sporting | 0-1 | CA Cerro | |
| 30.11.2021 | CA Cerro | 1-2 | Defensor Sporting | |
Central Español FC 1-1 Racing Club (URU) *
| 03.12.2021 | Racing Club (URU) | 1-1 | Central Español FC | |
| 01.12.2021 | Central Español FC | 0-0 | Racing Club (URU) | |