Haverfordwest 1-4 Aberystwyth Town
| 05.10.2010 | Aberystwyth Town | 3-0 | Haverfordwest | |
| 21.09.2010 | Haverfordwest | 1-1 | Aberystwyth Town | |
Llanelli Town 3-2 Port Talbot
| 05.10.2010 | Port Talbot | 0-2 | Llanelli Town | |
| 21.09.2010 | Llanelli Town | 1-2 | Port Talbot | |
Prestatyn Town 4-4 Bangor City
| 05.10.2010 | Bangor City | 2-1 | Prestatyn Town | |
| 21.09.2010 | Prestatyn Town | 3-2 | Bangor City | |
*The New Saints 4-2 Airbus UK Broughton
| 06.10.2010 | Airbus UK Broughton | 2-2 | The New Saints | |
| 21.09.2010 | The New Saints | 2-0 | Airbus UK Broughton | |